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Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridge.

Antimicrobial agents and chemotherapy - 1 Dec 2014

Aldred Katie J, Breland Erin J, McPherson Sylvia A, Turnbough Charles L, Kerns Robert J, Osheroff Neil

Abstract excerpt

The rise in quinolone resistance is threatening the clinical use of this important class of broad-spectrum antibacterials. Quinolones kill bacteria by increasing the level of DNA strand breaks generated by the type II topoisomerases gyrase and topoisomerase IV. Most commonly, resistance is caused by mutations in the serine and acidic amino acid residues that anchor a water-metal ion bridge that facilitates...

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Identifiers

PMID: 25246407
DOI: 10.1128/AAC.03734-14
PMCID: PMC4249509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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