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Article

Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance.

Journal of bacteriology - 1 Jul 1995

Muñoz R, Bustamante M, de la Campa A G

Abstract excerpt

We report the cloning of the gyrB gene from Streptococcus pneumoniae 533 that carries the nov-1 allele. The gyrB gene codes for a protein homologous to the gyrase B subunit of archaebacteria and eubacteria. The same amino acid substitution (Ser-127 to Leu) confers novobiocin resistance on four isolates of S. pneumoniae. This amino acid position is equivalent to Val-120 of Escherichia coli GyrB, a residue that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 7608096
DOI: 10.1128/jb.177.14.4166-4170.1995
PMCID: PMC177155

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Source receipt: pubmed, retrieved 7 Sept 2026.

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