Article
Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance.
Journal of bacteriology - 1 Jul 1995
Muñoz R, Bustamante M, de la Campa A G
Abstract excerpt
We report the cloning of the gyrB gene from Streptococcus pneumoniae 533 that carries the nov-1 allele. The gyrB gene codes for a protein homologous to the gyrase B subunit of archaebacteria and eubacteria. The same amino acid substitution (Ser-127 to Leu) confers novobiocin resistance on four is...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Genes, Bacterial
- Leucine
- Molecular Sequence Data
- Mutation
- Novobiocin
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Serine
- Streptococcus pneumoniae