Mutants suppressing novobiocin hypersensitivity of a mukB null mutation.

doi:10.1128/JB.185.13.3690-3695.2003

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Article

Mutants suppressing novobiocin hypersensitivity of a mukB null mutation.

Journal of bacteriology - 1 Jul 2003

Adachi Shun, Hiraga Sota

Abstract excerpt

The mukB gene is essential for the partitioning of sister chromosomes in Escherichia coli. A mukB null mutant is hypersensitive to the DNA gyrase inhibitor novobiocin. In this work, we isolated mutants suppressing the novobiocin hypersensitivity of the mukB null mutation. All suppressor mutations are localized in or near the gyrB gene, and the four tested clones have an amino acid substitution in the DNA gyrase...

Topics

Bacterial Proteins
Chromosomal Proteins, Non-Histone
Chromosomes, Bacterial
DNA Gyrase
Drug Resistance, Bacterial
Enzyme Inhibitors
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Microbial Sensitivity Tests
Mutation
Novobiocin
Suppression, Genetic
X-Rays

Source

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Identifiers

PMID: 12813060
DOI: 10.1128/JB.185.13.3690-3695.2003
PMCID: PMC161581

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