Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Localization and characterization of serologic epitopes on HLA-A2.

Human immunology - 1 Mar 1992

Hogan K T, Brown S L

Abstract excerpt

A panel of cells expressing 68 different mutant HLA-A2 genes was generated by site-directed mutagenesis and DNA-mediated gene transfer in order to define the regions of class I MHC molecules that contribute to the epitopes recognized by mAb. Each of the variant HLA-A2 molecules differed from HLA-A2.1 by a single amino acid substitution. The substitutions were located in both the alpha-helices and beta-strands of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross Reactions
Share to Epitopes
Share to HLA-A2 Antigen

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Structure-Activity Relationship

Share to Transfection

Source

Identifiers

PMID: 1377666
DOI: 10.1016/0198-8859(92)90070-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Localization and characterization of serologic epitopes on HLA-A2.PMID 1377666Read ↗

Limited regions of the alpha 2-domain alpha-helix control anti-A2 allorecognition: an analysis using a panel of A2 mutants.Semantic proximity Read ↗

HLA-A2 subtypes are functionally distinct in peptide binding and presentation.Semantic proximity Read ↗

Influence on antibody recognition of amino acid substitutions in the cleft of HLA-DQ2 molecules. Suggestive evidence of peptide-dependent epitopes.Semantic proximity Read ↗

HLA-A2-binding peptides cross-react not only within the A2 subgroup but also with other HLA-A-locus allelic products.Semantic proximity Read ↗

Structural and Functional Studies with Antibodies to the Integrin β2 SubunitSemantic proximity Read ↗

The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.Semantic proximity Read ↗

MHC allele-specific molecular features determine peptide/HLA-A2 conformations that are recognized by HLA-A2-restricted T cell receptors.Semantic proximity Read ↗

Strategic mutations in the class I major histocompatibility complex HLA-A2 independently affect both peptide binding and T cell receptor recognition.Semantic proximity Read ↗

Effects of beta2-microglobulin mutations on the alpha-1 helical region of H2-Ld.Semantic proximity Read ↗

Binding and presentation of peptides derived from melanoma antigens MART-1 and glycoprotein-100 by HLA-A2 subtypes. Implications for peptide-based immunotherapy.Semantic proximity Read ↗

Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2Semantic proximity Read ↗

A mutated HLA-A2 molecule recognized by autologous cytotoxic T lymphocytes on a human renal cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.