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Article

Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.

Genes & development - 1 Apr 1996

Godley L A, Kopp J B, Eckhaus M, Paglino J J, Owens J, Varmus H E

Abstract excerpt

Transgenic mice expressing wild-type murine p53 under the control of the mouse mammary tumor virus long terminal repeat (MMTV LTR) undergo progressive renal failure due to abnormal kidney development. Similar phenotypes are observed in two transgenic lines that express wild-type p53 within the ureteric bud but not in transgenic animals expressing a dominant-negative p53 mutant allele. Defective differentiation of...

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Identifiers

PMID: 8846920
DOI: 10.1101/gad.10.7.836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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