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Article

Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice.

Journal of the American Society of Nephrology : JASN - 1 Jun 2006

Dziarmaga Alison, Eccles Michael, Goodyer Paul

Abstract excerpt

The molecular mechanisms that set congenital nephron number are unknown. However, humans with modest suboptimal nephron number may be at increased risk for essential hypertension, and those with more severe nephron deficits at birth may develop progressive renal insufficiency. A model of branching morphogenesis during fetal kidney development in which the extent of ureteric bud arborization is dependent on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16672320
DOI: 10.1681/ASN.2005101074

Genes

BCL2
PAX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice.PMID 16672320Read ↗

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Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax2(1Neu) +/- mutant mice.Semantic proximity Read ↗

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The Pro-Apoptotic Protein Bim Is a MicroRNA Target in Kidney ProgenitorsSemantic proximity Read ↗

Bmp7 Maintains Undifferentiated Kidney Progenitor Population and Determines Nephron Numbers at BirthSemantic proximity Read ↗

Reduced Pax2 Gene Dosage Increases Apoptosis and Slows the Progression of Renal Cystic DiseaseSemantic proximity Read ↗

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