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Article

Processing of the yeast pre-rRNA at sites A(2) and A(3) is linked.

RNA (New York, N.Y.) - 1 Jan 1996

Allmang C, Henry Y, Morrissey J P, Wood H, Petfalski E, Tollervey D

Abstract excerpt

Cleavage of the yeast pre-rRNA at site A(2) in internal transcribed spacer 1 (ITS1) requires multiple snoRNP species, whereas cleavage at site A(3),located 72 nt 3' in ITS1, requires Rnase MRP. Analyses of mutations in the pre- rRNA have revealed an unexpected link between processing at A(2) and A(3). Small substitution mutations in the 3' flanking sequence at A(2) inhibit processing at site A(3), whereas a small...

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PMID: 8846297
PMCID: PMC1369351

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Research trail→

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Processing of the yeast pre-rRNA at sites A(2) and A(3) is linked.PMID 8846297Read ↗

Recognition of cleavage site A(2) in the yeast pre-rRNA.Semantic proximity Read ↗

The 5' end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.Semantic proximity Read ↗

The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA.Semantic proximity Read ↗

Role of the ITS2-proximal stem and evidence for indirect recognition of processing sites in pre-rRNA processing in yeast.Semantic proximity Read ↗

Two distinct recognition signals define the site of endonucleolytic cleavage at the 5'-end of yeast 18S rRNA.Semantic proximity Read ↗

Base pairing between U3 small nucleolar RNA and the 5' end of 18S rRNA is required for pre-rRNA processing.Semantic proximity Read ↗

RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.Semantic proximity Read ↗

Trypanosoma brucei 5'ETS A'-cleavage is directed by 3'-adjacent sequences, but not two U3 snoRNA-binding elements, which are all required for subsequent pre-small subunit rRNA processing events.Semantic proximity Read ↗

Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p.Semantic proximity Read ↗

RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.Semantic proximity Read ↗

The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.Semantic proximity Read ↗

The spacing between functional Cis-elements of U3 snoRNA is critical for rRNA processing.Semantic proximity Read ↗

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