Article
Two distinct recognition signals define the site of endonucleolytic cleavage at the 5'-end of yeast 18S rRNA.
The EMBO journal - 2 Oct 1995
Venema J, Henry Y, Tollervey D
Abstract excerpt
Three of the four eukaryotic ribosomal RNA molecules (18S, 5.8S and 25-28S rRNA) are transcribed as a single precursor, which is subsequently processed into the mature species by a complex series of cleavage and modification reactions. Early cleavage at site A1 generates the mature 5'-end of 18S rRNA. Mutational analyses have identified a number of upstream regions in the 5' external transcribed spacer (5' ETS),...
Topics
- Base Sequence
- Conserved Sequence
- Endoribonucleases
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA Precursors
- RNA Processing, Post-Transcriptional
- RNA, Ribosomal, 18S
- Saccharomyces cerevisiae