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Article

The 5' end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.

The EMBO journal - 15 May 1994

Henry Y, Wood H, Morrissey J P, Petfalski E, Kearsey S, Tollervey D

Abstract excerpt

We have developed techniques for the detailed analysis of cis-acting sequences in the pre-rRNA of Saccharomyces cerevisiae and used these to study the processing of internal transcribed spacer 1 (ITS1) leading to the synthesis of 5.8S rRNA. As is the case for many eukaryotes, the 5' end of yeast 5.8S rRNA is heterogeneous; we designate the major, short form 5.8S(S), and the minor form (which is seven or eight...

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Source

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Identifiers

PMID: 7515008
DOI: 10.1002/j.1460-2075.1994.tb06530.x
PMCID: PMC395111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 5' end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.PMID 7515008Read ↗

Two distinct recognition signals define the site of endonucleolytic cleavage at the 5'-end of yeast 18S rRNA.Semantic proximity Read ↗

Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p.Semantic proximity Read ↗

The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA.Semantic proximity Read ↗

Processing of the yeast pre-rRNA at sites A(2) and A(3) is linked.Semantic proximity Read ↗

The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.Semantic proximity Read ↗

Processing of eukaryotic pre-rRNA: the role of the transcribed spacers.Semantic proximity Read ↗

Separate structural elements within internal transcribed spacer 1 of Saccharomyces cerevisiae precursor ribosomal RNA direct the formation of 17S and 26S rRNA.Semantic proximity Read ↗

The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.Semantic proximity Read ↗

RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.Semantic proximity Read ↗

RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.Semantic proximity Read ↗

Role of the ITS2-proximal stem and evidence for indirect recognition of processing sites in pre-rRNA processing in yeast.Semantic proximity Read ↗

Trypanosoma brucei 5'ETS A'-cleavage is directed by 3'-adjacent sequences, but not two U3 snoRNA-binding elements, which are all required for subsequent pre-small subunit rRNA processing events.Semantic proximity Read ↗

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