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Article

Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p.

Nucleic acids research - 1 Oct 2002

Eppens Noor A, Faber Alex W, Rondaij Mariska, Jahangir Roshan S, van Hemert Saskia, Vos Jan C, Venema Jaap, Raué Hendrik A

Abstract excerpt

Rrp5p is the only protein so far known to be required for the processing of yeast pre-rRNA at both the early sites A0, A1 and A2 leading to 18S rRNA and at site A3, the first step specific for the pathway leading to 5.8S/25S rRNA. Previous in vivo mutational analysis of Rrp5p demonstrated that the first 8 of its 12 S1 RNA-binding motifs are involved in the formation of the 'short' form of 5.8S rRNA (5.8S(S)),...

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Identifiers

PMID: 12364601
DOI: 10.1093/nar/gkf538
PMCID: PMC140538

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Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p.PMID 12364601Read ↗

The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA.Semantic proximity Read ↗

RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.Semantic proximity Read ↗

Deletion of the three distal S1 motifs of Saccharomyces cerevisiae Rrp5p abolishes pre-rRNA processing at site A(2) without reducing the production of functional 40S subunits.Semantic proximity Read ↗

The 5' end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.Semantic proximity Read ↗

The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.Semantic proximity Read ↗

Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.Semantic proximity Read ↗

Processing of the yeast pre-rRNA at sites A(2) and A(3) is linked.Semantic proximity Read ↗

The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.Semantic proximity Read ↗

High dosage of the small nucleolar RNA snR10 specifically suppresses defects of a yeast rrp5 mutant.Semantic proximity Read ↗

The roles of S1 RNA-binding domains in Rrp5's interactions with pre-rRNA.Semantic proximity Read ↗

Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation.Semantic proximity Read ↗

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