Article
Role of the ITS2-proximal stem and evidence for indirect recognition of processing sites in pre-rRNA processing in yeast.
Nucleic acids research - 15 May 2001
Côté C A, Peculis B A
Abstract excerpt
Eucaryotic ribosome biogenesis involves many cis-acting sequences and trans-acting factors, including snoRNAS: We have used directed mutagenesis of rDNA plasmids in yeast to identify critical sequence and structural elements within and flanking the ITS2-proximal stem. This base paired structure, present in the mature ribosome, is formed between the 5'-end of 25S and the 3'-end of 5.8S rRNAS: Previously we...
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