Article
Recognition of cleavage site A(2) in the yeast pre-rRNA.
RNA (New York, N.Y.) - 1 Jan 1996
Allmang C, Henry Y, Wood H, Morrissey J P, Petfalski E, Tollervey D
Abstract excerpt
Processing of the yeast pre-rRNA at site A(2) internal transcribed spacer 1(ITS1) has been shown to require several small nucleolar ribonucleoprotein particles (snoRNPs) as trans-acting factors. Here we report a detailed mutational analysis of the cid-acting signals required to specify the site of A(2) lie in the 3'-flanking sequence; deletion or substitution of nucleotides in this region strongly inhibits...
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