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Article

RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.

The EMBO journal - 15 Oct 1996

Venema J, Tollervey D

Abstract excerpt

Three of the four eukaryotic ribosomal RNA molecules (18S, 5.8S and 25-28S) are synthesized as a single precursor which is subsequently processed into the mature rRNAs by a complex series of cleavage and modification reactions. In the yeast Saccharomyces cerevisiae, the early pre-rRNA cleavages at sites A0, A1 and A2, required for the synthesis of 18S rRNA, are inhibited in strains lacking RNA or protein...

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Identifiers

PMID: 8896463
PMCID: PMC452314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.PMID 8896463Read ↗

Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p.Semantic proximity Read ↗

Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.Semantic proximity Read ↗

Deletion of the three distal S1 motifs of Saccharomyces cerevisiae Rrp5p abolishes pre-rRNA processing at site A(2) without reducing the production of functional 40S subunits.Semantic proximity Read ↗

The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.Semantic proximity Read ↗

High dosage of the small nucleolar RNA snR10 specifically suppresses defects of a yeast rrp5 mutant.Semantic proximity Read ↗

Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae.Semantic proximity Read ↗

The 5' end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.Semantic proximity Read ↗

Characterization of three new snRNAs from Saccharomyces cerevisiae: snR34, snR35 and snR36.Semantic proximity Read ↗

Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation.Semantic proximity Read ↗

Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2.Semantic proximity Read ↗

Processing of the yeast pre-rRNA at sites A(2) and A(3) is linked.Semantic proximity Read ↗

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