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Article

The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.

Genes & development - 15 Feb 1996

Mitchell P, Petfalski E, Tollervey D

Abstract excerpt

Eukaryotic rRNAs (with the exception of 5S rRNA) are synthesized from a contiguous pre-rRNA precursor by a complex series of processing reactions. Final maturation of yeast 5.8S rRNA involves processing of a 3'-extended, 7S precursor that contains approximately 140 nucleotides of the internal transcribed spacer 2 (ITS2) region. In yeast strains carrying the temperature-sensitive (ts) rrp4-1 mutation, 5.8S rRNA...

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Identifiers

PMID: 8600032
DOI: 10.1101/gad.10.4.502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.PMID 8600032Read ↗

The 5' end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.Semantic proximity Read ↗

Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p.Semantic proximity Read ↗

The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.Semantic proximity Read ↗

RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.Semantic proximity Read ↗

Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation.Semantic proximity Read ↗

The Saccharomyces cerevisiae small GTPase, Gsp1p/Ran, is involved in 3' processing of 7S-to-5.8S rRNA and in degradation of the excised 5'-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome.Semantic proximity Read ↗

Essential structural features in the Schizosaccharomyces pombe pre-rRNA 5' external transcribed spacer.Semantic proximity Read ↗

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