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Article

The spacing between functional Cis-elements of U3 snoRNA is critical for rRNA processing.

Journal of molecular biology - 30 Jun 2000

Borovjagin A V, Gerbi S A

Abstract excerpt

The sequences and structural features of Xenopus laevis U3 small nucleolar RNA (snoRNA) necessary for pre-rRNA cleavage at sites 1 and 2 to form 18 S rRNA were assayed by depletion/rescue experiments in Xenopus oocytes. Mutagenesis results demonstrated that the putative stem of U3 domain I is unnecessary for 18 S rRNA processing. A model consistent with earlier experimental data is proposed for the structure of...

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Source

Identifiers

PMID: 10864498
DOI: 10.1006/jmbi.2000.3798

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