Article
A recessive mutant of the U937 cell line acquired resistance to anti-Fas and anti-p55 tumor necrosis factor receptor antibody-induced apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1995
Noguchi K, Naito M, Kataoka S, Yonehara S, Tsuruo T
Abstract excerpt
Human monocytic leukemia U937 cells readily undergo apoptosis when cells are treated with various stimuli including antitumor agents, tumor necrosis factor (TNF)-alpha and anti-Fas antibody. However, the signal transduction mechanism resulting in apoptosis is unclear. To study the mechanism of ap...
Topics
- Antibodies
- Apoptosis
- Cell Line
- Cycloheximide
- DNA
- Etoposide
- Genes, Recessive
- Humans
- Hybrid Cells
- Monocytes
- Mutation
- Phenotype
- Protein Synthesis Inhibitors
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Proto-Oncogene Proteins c-myc
- Receptors, Tumor Necrosis Factor
- Signal Transduction