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Article

Apaf-1 protein deficiency confers resistance to cytochromec–dependent apoptosis in human leukemic cells

15 Jul 2001

Abstract excerpt

The human leukemia cell lines K562, CEM, CEM/VLB(100), human leukemic blasts, and the bladder cancer J82 cell line have different sensitivities to UV light-induced apoptosis. It is reported that resistance to UV light-induced apoptosis occurs at a point in the apoptotic pathway upstream of caspase-3 but downstream of mitochondrial cytochrome c release. It is demonstrated that the block is due to deficiency of...

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PMID: 11435311
DOI: 10.1182/blood.v98.2.414

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