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Article

Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis

15 May 2000

Abstract excerpt

Abnormality in the machinery of apoptosis is associated with a resistant phenotype of the tumor cell to chemotherapy. To determine the molecular basis of resistance to antitumor agent-induced apoptosis, we performed a complementary DNA (cDNA) subtractive hybridization with messenger RNA (mRNA) from human monocytic leukemia U937 and its variant UK711, which is resistant to apoptosis induced by antitumor agents. We...

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PMID: 10807791
DOI: 10.1182/blood.v95.10.3214

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