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Article

Contribution of a tyrosine side chain to ribonuclease A catalysis and stability.

Protein science : a publication of the Protein Society - 1 Aug 1996

Eberhardt E S, Wittmayer P K, Templer B M, Raines R T

Abstract excerpt

An intricate architecture of covalent bonds and noncovalent interactions appear to position the side chain of Lys 41 properly within the active site of bovine pancreatic ribonuclease A (RNase A). One of these interactions arises from Tyr 97, which is conserved in all 41 RNase A homologues of known sequence. Tyr 97 has a solvent-inaccessible side chain that donates a hydrogen bond to the main-chain oxygen of Lys...

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Identifiers

PMID: 8844858
DOI: 10.1002/pro.5560050823
PMCID: PMC2143487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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