Article
Functional role of putative critical residues in Mycobacterium tuberculosis RNase P protein.
The international journal of biochemistry & cell biology - 1 Sept 2016
Singh Alla, Ubaid-Ullah Shah, Batra Janendra K
Abstract excerpt
RNase P is involved in processing the 5' end of pre-tRNA molecules. Bacterial RNase P contains a catalytic RNA subunit and a protein subunit. In this study, we have analyzed the residues in RNase P protein of M. tuberculosis that differ from the residues generally conserved in other bacterial RNase Ps. The residues investigated in the current study include the unique residues, Val27, Ala70, Arg72, Ala77, and...
Topics
- Amino Acid Sequence
- Enzyme Stability
- Kinetics
- Models, Molecular
- Mutation
- Mycobacterium tuberculosis
- Protein Conformation
- Protein Folding
- RNA
- Ribonuclease P
- Sequence Alignment
- Sequence Homology, Amino Acid
- Temperature