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Article

Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme.

Protein science : a publication of the Protein Society - 1 May 2009

Mooers Blaine H M, Baase Walter A, Wray Jonathan W, Matthews Brian W

Abstract excerpt

To try to resolve the loss of stability in the temperature-sensitive mutant of T4 lysozyme, Arg 96 --> His, all of the remaining 18 naturally occurring amino acids were substituted at site 96. Also, in response to suggestions that the charged residues Lys85 and Asp89, which are 5-8 A away, may have important effects, each of these amino acids was replaced with alanine. Crystal structures were determined for many...

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Identifiers

PMID: 19384988
DOI: 10.1002/pro.94
PMCID: PMC2771291

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