Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme.

doi:10.1038/330041a0

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Article

Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme.

Nature - 1 Jan 2000

Alber T, Sun D P, Wilson K, Wozniak J A, Cook S P, Matthews B W

Abstract excerpt

Measurements of changes in structure and stability caused by 13 different substitutions for threonine 157 in phage T4 lysozyme show that the most stable lysozyme variants contain hydrogen bonds analogous to those in the wild-type enzyme and that structural adjustments allow the protein to be surp...

Topics

Computer Simulation
Enzyme Stability
Escherichia coli
Hydrogen Bonding
Models, Molecular
Muramidase
Mutation
Protein Conformation
T-Phages
Thermodynamics
Threonine
X-Ray Diffraction

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