Article
Identification of mutations in the Ki-ras gene in human retinoblastoma.
Investigative ophthalmology & visual science - 1 Oct 1996
Bautista D, Emanuel J R, Granville C, Howard R, Costa J
Abstract excerpt
PURPOSE: To investigate the mutational status of the Ki-ras gene in retinoblastoma and to evaluate a correlation of the genotype with clinical and histopathologic variables. METHODS: Tumor samples were microdissected from sectioned archival paraffin-embedded tissue. Ki-ras genomic sequences (exons 1 and 2) were amplified by polymerase chain reaction then analyzed by single-strand conformation polymorphism and...
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