Article
Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2011
Wegman Pia, Ahlin Cecilia, Sorbe Bengt
Abstract excerpt
INTRODUCTION: A high incidence of K-Ras mutations has been identified in a variety of human cancers, especially in codon 12, 13, and 61. Nevertheless, the presence of K-Ras mutations in cervical cancer remains controversial. The aim of this study was to investigate possible mutations in exon 1 and 2 of the K-Ras gene and to assess whether K-Ras mutation status had prognostic and predictive significance and were...
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