Article
Genetic alterations in Ki-ras and Ha-ras genes in juvenile nasopharyngeal angiofibromas and head and neck cancer.
Sao Paulo medical journal = Revista paulista de medicina - 6 May 1999
Coutinho C M, Bassini A S, Gutiérrez L G, Butugan O, Kowalski L P, Brentani M M, Nagai M A
Abstract excerpt
CONTEXT: Ras gene mutations have been associated to a wide range of human solid tumors. Members of the ras gene family (Ki-ras, Ha-ras and N-ras) are structurally related and code for a protein (p21) known to play an important role in the regulation of normal signal transduction and cell growth. The frequency of ras mutations is different from one type of tumor to another, suggesting that point mutations might be...
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