An isogenic haemolysin-deficient mutant of Haemophilus ducreyi lacks the ability to produce cytopathic effects on human foreskin fibroblasts.

doi:10.1046/j.1365-2958.1996.00615.x

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Article

An isogenic haemolysin-deficient mutant of Haemophilus ducreyi lacks the ability to produce cytopathic effects on human foreskin fibroblasts.

Molecular microbiology - 1 Jul 1996

Palmer K L, Goldman W E, Munson R S

Abstract excerpt

The haemolysin of Haemophilus ducreyi is the newest member of the Proteus/Serratia family of pore-forming toxins. In order to assess the role of the haemolysin in virulence, we constructed an isogenic haemolysin-deficient mutant of H. ducreyi strain 35000 This strain, designated 35000-3, lacks de...

Topics

Cell Line
Chancroid
Fibroblasts
Haemophilus ducreyi
HeLa Cells
Hemolysin Proteins
Humans
Male
Mutation
Plasmids
Virulence

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