Article
Characterization of Haemophilus ducreyi cdtA, cdtB, and cdtC mutants in in vitro and in vivo systems.
Infection and immunity - 1 Sept 2001
Lewis D A, Stevens M K, Latimer J L, Ward C K, Deng K, Blick R, Lumbley S R, Ison C A, Hansen E J
Abstract excerpt
Haemophilus ducreyi expresses a soluble cytolethal distending toxin (CDT) that is encoded by the cdtABC gene cluster and can be detected in culture supernatant fluid by its ability to kill HeLa cells. The cdtA, cdtB, and cdtC genes of H. ducreyi were cloned independently into plasmid vectors, and their encoded proteins expressed singly or in various combinations in an Escherichia coli background. All three gene...
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