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Target Cell Range of <i>Haemophilus ducreyi</i> Hemolysin and Its Involvement in Invasion of Human Epithelial Cells

1 Aug 1999

Abstract excerpt

Haemophilus ducreyi, the causative agent of chancroid, produces a hemolysin, whose role in virulence is not well defined. To assess the possible role of hemolysin in pathogenesis, we evaluated its target cell range by using wild-type H. ducreyi 35000, nonhemolytic mutants with the hemolysin structural gene deleted, and isogenic strains expressing different amounts of hemolytic activity. The cytotoxicity of the...

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PMID: 10417132
DOI: 10.1128/iai.67.8.3740-3749.1999

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