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Article

DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma.

International journal of oncology - 1 Jul 2003

Park Sang-Won, Durkin Marian E, Thorgeirsson Snorri S, Popescu Nicholas C

Abstract excerpt

The DLC-1 gene encoding a regulator of the Rho family of small GTPases is altered in breast, prostate, colon, and liver cancer and has several characteristics of a tumor suppressor gene. DLC-1 overexpression causes inhibition of in vitro growth of liver tumor cells and complete suppression of in vivo tumorigenicity of breast tumor cells. Inactivation and aberrant expression of DLC-1 in human hepatocellular...

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Identifiers

PMID: 12792785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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