Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor.

Endocrinology - 1 Oct 2012

Zhao Li, Zhu Xuguang, Won Park Jeong, Fozzatti Laura, Willingham Mark, Cheng Sheue-yann

Abstract excerpt

Mutations of the thyroid hormone receptor-β gene (THRB) cause resistance to thyroid hormone (RTH). A mouse model of RTH harboring a homozygous thyroid hormone receptor (TR)-β mutation known as PV (Thrb(PV/PV) mouse) spontaneously develops follicular thyroid cancer (FTC). Similar to RTH patients with mutations of two alleles of the THRB gene, the Thrb(PV/PV) mouse exhibits elevated thyroid hormones accompanied by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Thyroid Gland

Share to Thyroid Hormone Receptors beta

Share to Thyroid Hormones

Share to Thyroid Neoplasms

Share to Thyrotropin

Source

Open in PubMed Open full text

Identifiers

PMID: 22919057
DOI: 10.1210/en.2012-1600
PMCID: PMC3512015

Genes

THRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor.PMID 22919057Read ↗

Mice with a Mutation in the Thyroid Hormone Receptor β Gene Spontaneously Develop Thyroid Carcinoma: A Mouse Model of Thyroid CarcinogenesisSemantic proximity Read ↗

Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors.Semantic proximity Read ↗

Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.Semantic proximity Read ↗

An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis.Semantic proximity Read ↗

Novel oncogenic actions of TRbeta mutants in tumorigenesis.Semantic proximity Read ↗

A tumor suppressor role for thyroid hormone beta receptor in a mouse model of thyroid carcinogenesis.Semantic proximity Read ↗

Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma.Semantic proximity Read ↗

Marked potentiation of the dominant negative action of a mutant thyroid hormone receptor beta in mice by the ablation of one wild-type beta allele.Semantic proximity Read ↗

A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor.Semantic proximity Read ↗

Compensatory role of thyroid hormone receptor (TR) alpha 1 in resistance to thyroid hormone: study in mice with a targeted mutation in the TR beta gene and deficient in TR alpha 1.Semantic proximity Read ↗

Thyroid hormone receptor beta mutations in the 'hot-spot region' are rare events in thyroid carcinomas.Semantic proximity Read ↗

Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.