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Article

Genomic interval engineering of mice identifies a novel modulator of triglyceride production.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2000

Zhu Y, Jong M C, Frazer K A, Gong E, Krauss R M, Cheng J F, Boffelli D, Rubin E M

Abstract excerpt

To accelerate the biological annotation of novel genes discovered in sequenced regions of mammalian genomes, we are creating large deletions in the mouse genome targeted to include clusters of such genes. Here we describe the targeted deletion of a 450-kb region on mouse chromosome 11, which, based on computational analysis of the deleted murine sequences and human 5q orthologous sequences, codes for nine...

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Identifiers

PMID: 10655497
DOI: 10.1073/pnas.97.3.1137
PMCID: PMC15548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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