Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

The Journal of clinical investigation - 1 Sept 2005

Engelking Luke J, Liang Guosheng, Hammer Robert E, Takaishi Kiyosumi, Kuriyama Hiroshi, Evers Bret M, Li Wei-Ping, Horton Jay D, Goldstein Joseph L, Brown Michael S

Abstract excerpt

End-product feedback inhibition of cholesterol synthesis was first demonstrated in living animals by Schoenheimer 72 years ago. Current studies define Insig proteins as essential elements of this feedback system in mouse liver. In cultured cells, Insig proteins are required for sterol-mediated inhibition of the processing of sterol regulatory element-binding proteins (SREBPs) to their nuclear forms. We produced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cholesterol

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cholesterol, Dietary

Share to Feedback, Physiological

Share to Gene Targeting

Share to Lipids

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 16100574
DOI: 10.1172/JCI25614
PMCID: PMC1184040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.PMID 16100574Read ↗

Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH PathogenesisSemantic proximity Read ↗

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.Semantic proximity Read ↗

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Semantic proximity Read ↗

Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.Semantic proximity Read ↗

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.Semantic proximity Read ↗

SREBPs: sterol-regulated transcription factorsSemantic proximity Read ↗

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.Semantic proximity Read ↗

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.Semantic proximity Read ↗

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).Semantic proximity Read ↗

IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbitsSemantic proximity Read ↗

Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.Semantic proximity Read ↗

Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.