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Article

E1A- and E1B-Double mutant replicating adenovirus elicits enhanced oncolytic and antitumor effects.

Human gene therapy - 1 Sept 2007

Kim Jaesung, Kim Joo-Hang, Choi Kyung-Ju, Kim Pyung-Hwan, Yun Chae-Ok

Abstract excerpt

Gene-modified replication-competent adenoviruses (Ads) are emerging as a promising new modality for the treatment of cancer. We have previously shown that E1B 19kDa and E1B 55kDa gene-deleted Ad (Ad-DeltaE1B19/55) exhibits improved tumor-specific replication and cell lysis, leading to an enhanced antitumor effect. In an effort to increase cancer cell selectivity of a replicating adenovirus, we first generated 11...

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PMID: 17725410
DOI: 10.1089/hum.2006.167

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