Oncogenic amino acid substitutions in the inhibitory rap-1A protein cause it to adopt a ras-p21-like conformation as computed using molecular dynamics.

Abstract excerpt

rap-1A is a membrane-bound G-protein in the ras superfamily that, like the ras-p21 protein, is activated by binding GTP in place of GDP. When activated, however, this protein inhibits the action of ras-p21, which is to induce mitogenesis in cells A chimeric protein containing RAS-p21 residues 1-6...

Topics

• Amino Acid Sequence
• Amino Acids
• Binding Sites
• GTP-Binding Proteins
• Models, Molecular
• Molecular Sequence Data
• Mutation
• Oncogene Protein p21(ras)
• Protein Conformation
• Recombinant Proteins
• Sequence Homology, Amino Acid
• rap GTP-Binding Proteins