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Article

Mechanistic Differences of Activation of Rac1P29S and Rac1A159V.

The journal of physical chemistry. B - 22 Apr 2021

Senyuz Simge, Jang Hyunbum, Nussinov Ruth, Keskin Ozlem, Gursoy Attila

Abstract excerpt

Rac1 is a small GTPase that plays key roles in actin reorganization, cell motility, and cell survival/growth as well as in various cancer types and neurodegenerative diseases. Similar to other Ras superfamily GTPases, Rac1 switches between active GTP-bound and inactive GDP-bound states. Switch I and II regions open and close during GDP/GTP exchange. P29S and A159V (paralogous to K-RasA146) mutations are the two...

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Identifiers

PMID: 33848152
DOI: 10.1021/acs.jpcb.1c00883
PMCID: PMC8154616

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