Comparison of the low energy conformations of an oncogenic and a non-oncogenic p21 protein, neither of which binds GTP or GDP.

doi:10.1007/BF01891982

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Article

Comparison of the low energy conformations of an oncogenic and a non-oncogenic p21 protein, neither of which binds GTP or GDP.

Journal of protein chemistry - 1 Feb 1994

Liwo A, Gibson K D, Scheraga H A, Brandt-Rauf P W, Monaco R, Pincus M R

Abstract excerpt

Oncogenic p21 protein, encoded by the ras-oncogene, that causes malignant transformation of normal cells and many human tumors, is almost identical in sequence to its normal protooncogene-encoded counterpart protein, except for the substitution of arbitrary amino acids for the normally occurring...

Topics

Crystallography, X-Ray
Guanosine Diphosphate
Guanosine Triphosphate
Mutation
Oncogene Protein p21(ras)
Protein Conformation

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