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Article

Conserved helix 7 tyrosine functions as an activation relay in the serotonin 5HT(2C) receptor.

Brain research. Molecular brain research - 8 Dec 2000

Rosendorff A, Ebersole B J, Sealfon S C

Abstract excerpt

The function of the helix VII Tyr in the conserved Asn-Pro-X-X-Tyr segment of rhodopsin-like G protein coupled receptors has been investigated in many receptors. Various effects of site-directed mutation of this locus have been found, including altered coupling, sequestration and agonist affinity. We report the first constitutively active mutations of this Tyr. In the serotonin 5HT(2C) receptor, substituting Ala...

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Identifiers

PMID: 11113535
DOI: 10.1016/s0169-328x(00)00227-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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