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Article

Immune-Mediated Control of a Dormant Neurotropic RNA Virus Infection

28 Jun 2019

Abstract excerpt

Viral infections of neurons are often not cytopathic; thus, once-infected neurons survive, and viral RNAs can be detected long after apparent viral control. These RNAs are generally considered viral fossils, unlikely to contribute to central nervous system (CNS) disease. Using a mouse model of measles virus (MV) neuronal infection, we show that MV RNA is maintained in the CNS of infected mice long after acute...

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PMID: 31270232
DOI: 10.1128/jvi.00241-19

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