Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Organ-Specific Attenuation of Murine Hepatitis Virus Strain A59 by Replacement of Catalytic Residues in the Putative Viral Cyclic Phosphodiesterase ns2

29 Jan 2009

Abstract excerpt

The Murine hepatitis virus (MHV) strain A59 ns2 protein is a 30-kDa nonstructural protein that is expressed from a subgenomic mRNA in the cytoplasm of virus-infected cells. Its homologs are also encoded in other closely related group 2a coronaviruses and more distantly related toroviruses. Together, these proteins comprise a subset of a large superfamily of 2H phosphoesterase proteins that are distinguished by a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to Hepatitis C virus research
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19176619
DOI: 10.1128/jvi.02203-08

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organ-Specific Attenuation of Murine Hepatitis Virus Strain A59 by Replacement of Catalytic Residues in the Putative Viral Cyclic Phosphodiesterase ns2PMID 19176619Read ↗

Recombinant Mouse Hepatitis Virus Strain A59 from Cloned, Full-Length cDNA Replicates to High Titers In Vitro and Is Fully Pathogenic In VivoSemantic proximity Read ↗

Mouse hepatitis virus liver pathology is dependent on ADP-ribose-1''-phosphatase, a viral function conserved in the alpha-like supergroup.Semantic proximity Read ↗

The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced EncephalitisSemantic proximity Read ↗

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis.Semantic proximity Read ↗

Analysis of Murine Hepatitis Virus Strain A59 Temperature-Sensitive Mutant TS-LA6 Suggests that nsp10 Plays a Critical Role in Polyprotein ProcessingSemantic proximity Read ↗

Genetic analysis of Murine hepatitis virus nsp4 in virus replication.Semantic proximity Read ↗

Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice.Semantic proximity Read ↗

A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing.Semantic proximity Read ↗

Biochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease.Semantic proximity Read ↗

Attenuation of mouse hepatitis virus by deletion of the LLRKxGxKG region of Nsp1.Semantic proximity Read ↗

Antiviral Effect of Antimicrobial Peptoids and a Murine Model of Respiratory Coronavirus InfectionSemantic proximity Read ↗

Enhanced Virulence Mediated by the Murine Coronavirus, Mouse Hepatitis Virus Strain JHM, Is Associated with a Glycine at Residue 310 of the Spike GlycoproteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.