Article
Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.
Stem cells (Dayton, Ohio) - 1 May 2015
Zeng Yi, Broxmeyer Hal E, Staser Karl, Chitteti Brahmananda Reddy, Park Su-Jung, Hahn Seongmin, Cooper Scott, Sun Zejin, Jiang Li, Yang XianLin, Yuan Jin, Kosoff Rachelle, Sandusky George, Srour Edward F, Chernoff Jonathan, Clapp D Wade
Abstract excerpt
p21-Activated kinase 2 (Pak2), a serine/threonine kinase, has been previously shown to be essential for hematopoietic stem cell (HSC) engraftment. However, Pak2 modulation of long-term hematopoiesis and lineage commitment remain unreported. Using a conditional Pak2 knockout mouse model, we found that disruption of Pak2 in HSCs induced profound leukopenia and a mild macrocytic anemia. Although loss of Pak2 in HSCs...
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