Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1.

The Journal of biological chemistry - 26 Nov 1999

Ensenat D, Yao Z, Wang X S, Kori R, Zhou G, Lee S C, Tan T H

Abstract excerpt

Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family and an upstream activator of the c-Jun N-terminal kinase (JNK) signaling cascade. HPK1 interacts, through its proline-rich domains, with growth factor receptor-bound 2 (Grb2), CT10-regulated kinase (Crk), and Crk-like (CrkL) adaptor proteins. We identified a novel HPK1-interacting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HL-60 Cells
Share to JNK Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microfilament Proteins

Share to Mitogen-Activated Protein Kinases

Share to Proline

Share to src Homology Domains

Share to Tissue Distribution

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 10567356
DOI: 10.1074/jbc.274.48.33945

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1.PMID 10567356Read ↗

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.Semantic proximity Read ↗

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.Semantic proximity Read ↗

Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.Semantic proximity Read ↗

HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.Semantic proximity Read ↗

Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.Semantic proximity Read ↗

Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.Semantic proximity Read ↗

Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.Semantic proximity Read ↗

Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.Semantic proximity Read ↗

HPK1 competes with ADAP for SLP‐76 binding and <i>via</i> Rap1 negatively affects T‐cell adhesionSemantic proximity Read ↗

The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.Semantic proximity Read ↗

SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL.Semantic proximity Read ↗

Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.