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Article

Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase.

The Journal of biological chemistry - 16 Apr 2004

Machida Noriko, Umikawa Masato, Takei Kimiko, Sakima Nariko, Myagmar Bat-Erdene, Taira Kiyohito, Uezato Hiroshi, Ogawa Yoshihide, Kariya Ken-Ichi

Abstract excerpt

Little is known about the specific signaling roles of Rap2, a Ras family small GTP-binding protein. In a search for novel Rap2-interacting proteins by the yeast two-hybrid system, we isolated isoform 3 of the human mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), a previously described but uncharacterized isoform. Other isoforms of MAP4K4 in humans and mice are known as hematopoietic progenitor...

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PMID: 14966141
DOI: 10.1074/jbc.C300542200

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GCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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