Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.

doi:10.1093/carcin/17.9.1891

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Article

Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.

Carcinogenesis - 1 Sept 1996

Lear J T, Heagerty A H, Smith A, Bowers B, Payne C R, Smith C A, Jones P W, Gilford J, Yengi L, Alldersea J, Fryer A A, Strange R C

Abstract excerpt

The genetic factors that mediate the pathogenesis of multiple primary cutaneous basal cell carcinomas (BCC) are largely unclear. Thus, some patients suffer many BCC (>30) and/or rapid accrual (number of tumours/year from first presentation) of further lesions. We have studied, in 827 English Cauc...

Topics

Adult
Aged
Carcinoma, Basal Cell
Cross-Sectional Studies
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP2D6
England
Eye Color
Female
Genotype
Glutathione Transferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Isoenzymes

Longitudinal Studies

Male

Polymorphism, Genetic

Sex Characteristics

Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8824510
DOI: 10.1093/carcin/17.9.1891

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8824510-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.PMID 8824510Read ↗

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Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype.Semantic proximity Read ↗

Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender.Semantic proximity Read ↗

Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours.Semantic proximity Read ↗

Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours.Semantic proximity Read ↗

Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system.Semantic proximity Read ↗

Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.Semantic proximity Read ↗

Basal cell carcinomas: association of allelic variants with a high-risk subgroup of patients with the multiple presentation phenotype.Semantic proximity Read ↗

Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.Semantic proximity Read ↗

Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction.Semantic proximity Read ↗

Susceptibility and modifier genes in cutaneous basal cell carcinomas and their associations with clinical phenotype.Semantic proximity Read ↗

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