Article
Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.
Carcinogenesis - 1 Sept 1996
Lear J T, Heagerty A H, Smith A, Bowers B, Payne C R, Smith C A, Jones P W, Gilford J, Yengi L, Alldersea J, Fryer A A, Strange R C
Abstract excerpt
The genetic factors that mediate the pathogenesis of multiple primary cutaneous basal cell carcinomas (BCC) are largely unclear. Thus, some patients suffer many BCC (>30) and/or rapid accrual (number of tumours/year from first presentation) of further lesions. We have studied, in 827 English Caucasians, the influence of polymorphism in carcinogen-metabolizing enzymes on susceptibility to this cancer. Accordingly,...
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