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Article

Susceptibility and modifier genes in cutaneous basal cell carcinomas and their associations with clinical phenotype.

Journal of photochemistry and photobiology. B, Biology - 1 Oct 2001

Ramachandran S, Fryer A A, Lovatt T, Lear J, Smith A G, Strange R C

Abstract excerpt

While ultraviolet radiation (UV) is critical in the pathogenesis of basal cell carcinomas (BCC), its role in determining the phenotypic variation shown by patients is unknown. Thus, patients manifest variation in BCC numbers, patterns of presentation and tumour site. We have used this diversity to classify patients into subgroups that are associated with different risks of developing tumours. Two phenotypes are...

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PMID: 11684446
DOI: 10.1016/s1011-1344(01)00194-4

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