Article
Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.
Cancer research - 1 May 1996
Yengi L, Inskip A, Gilford J, Alldersea J, Bailey L, Smith A, Lear J T, Heagerty A H, Bowers B, Hand P, Hayes J D, Jones P W, Strange R C, Fryer A A
Abstract excerpt
The influence of polymorphism in the glutathione S-transferase, GSTM3 gene on susceptibility to cutaneous basal cell carcinoma (BCC) has been investigated. We have reported previously two GSTM3 alleles, GSTM3*A and GSTM3*B, distinguished by a recognition motif for the YY1 transcription factor in GSTM3*B. In this study, immunohistochemistry was used to identify GSTM3 expression in the epidermis of skin samples...
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