Article
Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction.
The Journal of investigative dermatology - 1 Apr 1997
Lear J T, Smith A G, Bowers B, Heagearty A H, Jones P W, Gilford J, Alldersea J, Strange R C, Fryer A A
Abstract excerpt
Basal cell carcinoma (BCC) places increasing burdens on clinicians; incidence is rising and patients may develop multiple primary tumors. Although UV exposure is critical, many patients develop tumors at less-exposed sites, such as the trunk, suggesting a genetic predisposition. We previously sho...
Topics
- Aged
- Carcinoma, Basal Cell
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 Enzyme System
- Female
- Genotype
- Glutathione Transferase
- Humans
- Isoenzymes
- Male
- Middle Aged
- Risk Factors
- Skin Neoplasms
- Thoracic Neoplasms