Article
Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 1999
Ramachandran S, Lear J T, Ramsay H, Smith A G, Bowers B, Hutchinson P E, Jones P W, Fryer A A, Strange R C
Abstract excerpt
We previously reported associations between numbers of basal cell carcinomas (BCCs) and glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P450 (CYP2D6) genotypes. Thus, although GSTM1 AB is protective, GSTM1 null, GSTT1 null, and CYP2D6 EM are associated with increased numbers of lesions...
Topics
- Adult
- Biomarkers, Tumor
- Carcinoma, Basal Cell
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Environmental Exposure
- Female
- Follow-Up Studies
- Genotype
- Glutathione Transferase
- Humans
- Logistic Models
- Male