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Article

Coincidental alterations of p16INK4A/CDKN2 and other genes in human lung cancer cell lines.

Anticancer research - 1 Jan 2000

Fujishita T, Mizushima Y, Kashii T, Kobayashi M

Abstract excerpt

Cyclin-dependent kinase (CDK) inhibitor genes have recently been proposed as new tumor suppressor genes. To define the possible participation of CDK inhibitor genes in lung carcinogenesis, we investigated the alterations of p15INK4B, p16INK4A, p21Waf1, and p27Kip1 genes in 34 human lung cancer cell lines using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP), direct sequencing, and...

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PMID: 9673367

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