Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the chimeric protein product of the <i>CBFB‐MYH11</i> fusion gene in inv(16) leukemia cells

1 Jun 1996

Abstract excerpt

An expressed gene formed by fusion between the CBFB transcription factor gene and the smooth muscle myosin heavy chain gene MYH11 is consistently detected by reverse transcription polymerase chain reaction (RT-PCR) in patients who have acute myeloid leukemia (AML) subtype M4Eo with an inversion of chromosome 16. We have previously shown that a CBFB-MYH11 cDNA construct can produce a chimeric protein and transform...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Protein Degradation and Inhibitors
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8818654
DOI: 10.1002/(sici)1098-2264(199606)16:2<77::aid-gcc1>3.0.co;2-#

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the chimeric protein product of the <i>CBFB‐MYH11</i> fusion gene in inv(16) leukemia cellsPMID 8818654Read ↗

Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia–initiating CBFB::MYH11 oncofusion proteinSemantic proximity Read ↗

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates.Semantic proximity Read ↗

Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail.Semantic proximity Read ↗

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid LeukemiaSemantic proximity Read ↗

The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.Semantic proximity Read ↗

Acute Mixed Lineage Leukemia With an inv(8)(p11q13) Resulting in Fusion of the Genes for MOZ and TIF2Semantic proximity Read ↗

Molecular analysis of a new variant of the CBF beta-MYH11 gene fusion.Semantic proximity Read ↗

The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia.Semantic proximity Read ↗

Recurrent fusion of <i>MYB</i> and <i>NFIB</i> transcription factor genes in carcinomas of the breast and head and neckSemantic proximity Read ↗

Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.Semantic proximity Read ↗

Molecular identification of CBFbeta-MYH11 fusion transcripts in an AML M4Eo patient in the absence of inv16 or other abnormality by cytogenetic and FISH analyses--a rare occurrence.Semantic proximity Read ↗

Detection of CBFB/MYH11 transcripts in patients with inversion and other abnormalities of chromosome 16 at presentation and remissionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.