Recurrent fusion of <i>MYB</i> and <i>NFIB</i> transcription factor genes in carcinomas of the breast and head and neck

Abstract excerpt

The transcription factor gene MYB was identified recently as an oncogene that is rearranged/duplicated in some human leukemias. Here we describe a new mechanism of activation of MYB in human cancer involving gene fusion. We show that the t(6;9)(q22-23;p23-24) translocation in adenoid cystic carcinomas (ACC) of the breast and head and neck consistently results in fusions encoding chimeric transcripts predominantly...

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